Throughout Gossip Girl’s six years on the air much has changed. Dan went from being a Lonely Boy to a vindictive bestselling author. Nate runs a newspaper now, so we have to assume he learned to read at some point instead of using all his books as hiding places for weed.
One thing that has always stayed the same, however, is the often turbulent friendship between Serena and Blair. The blonde free spirit and the brunette schemer have one of the most complicated and interesting friendships on TV. As we prepare to say goodbye to our friends on the Upper East Side, let’s take a look back at the best BFFs Manhattan has ever seen.